If the SNAP is abnormal consider a concomitant neuropathy of different etiology or revise your diagnosis to something other than ALS Abnormal motor units in ALS SNAPS or sensory nerve action potentials should be characteristically normal in ALS as the disease affects the anterior horn cell, (Amyotrophy) a motor neuron disease. While the compound muscle action potential (CMAP) is normal initially, but in advanced disease gets lower (even absent) due to severe loss of axons. The motor unit potential (MUP) gets higher in MND. What is the motor amplitude? Is it pathologically higher or lower than normal in ALS/MND?
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